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South San Francisco, California, United States
Manager, Accounting
At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating. This role can sit in either our South San Francisco or Seattle office, and we are paying relocation to either site. 


  • Develop and own the clinical trial accounting process including review of contracts, review and interpretation of third-party materials
  • Perform R&D accruals including collaborations, manufacturing, and clinical accruals
  • Perform highly analytical, multi-dimensional and complex reconciliations, with related analysis
  • Prepare or review and approve complex transactions and higher-level dollar value transactions
  • Research, synthesize data; incorporate results from large amounts of data, identify trends in data, draw conclusions, develop solutions, present, and implement recommendations and create follow up analysis
  • Meet regularly with internal and external stakeholders to track accruals, forecast clinical trial enrollment, etc.  
  • Manage multiple concurrent projects, paying special attention to competing deadlines, complexity, and priority
  • Assist in the month-end closing process preparing journal entries, account reconciliations and other projects as assigned
  • Liaise with FP&A and business partners to record and reconcile accrual balances and assist with budget versus actual analyses
  • Ensure that effective internal controls are performed and maintained in areas of responsibility
  • Supports year-end financial audits and prepares certain disclosures for SEC fillings


  • Bachelor's degree with a major or emphasis in Accounting, Finance, or another related field; or
  • Master’s degree in accounting 


  • Minimum of 7 years of relevant accounting experience
  • CPA certification required
  • Experience working and thriving in a fast-paced environment
  • Biotech and Public company, “Big Four” firm experience


  • Advanced proficiency in business applications, especially Excel
  • Exceptional professional communication skills, including the ability to communicate information clearly and effectively at all levels of the organization and with external partners
  • Strong technical accounting capabilities (ASC 320, 360, 606, 730, 810, 840, etc.) and knowledge of US GAAP
  • Strong work ethic and demonstrated ability to independently prioritize workload based on organizational needs/demands
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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