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Seattle, Washington, United States
Scientist, Molecular Assay Development
Process Sciences
At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.

The Scientist, Molecular Assay Development will join a dynamic team of scientists in the Analytical Development (AD) group at Lyell. The successful candidate will develop and implement molecular assays (qPCR, dPCR, etc), assess and establish new technologies, and design/execute experiments to advance process development and characterize next generation engineered T-cell products. Participation in technology transfer of molecular assays to the QC team and other key projects will be required to help advance the pipeline.

We are recruiting a self-motivated and experienced Scientist in the Molecular Assays subteam of our Analytical Development group. The successful candidate will work closely with the Director of AD to train members of the team and participate in the tech transfer of analytical methods into QC. The successful candidate will have experience with molecular assay development activities in the cell and gene therapy space, demonstrated ability to mentor scientists, experience with assessing new technologies, experience delivering high quality results according to fast project timelines, and a deep understanding of the technological requirements to execute on the analytical strategy of a cellular therapy company.


  • Design, develop, execute and document analytical testing methods to study and characterize processes for the production of T cell therapies, primarily focused on molecular biology-based techniques, such as qPCR, ddPCR, Vector Copy Number (VCN). assessment, viral safety and identity testing residual protein and host cell DNA assessments.
  • Author, review and revise test methods and standard operating procedures (SOPs).
  • Provide analytical support in cross-functional project teams and investigation teams.
  • Lead analytical projects including but not limited to development of analytical control strategies and heightened characterization of cell therapy products.
  • Serve as key technical resource for the evaluation of new analytical technologies and their implementation within the AD group.
  • Develop and deliver scientific presentations, prepare clear and concise technical reports, participate in project teams, and contribute to regulatory filings.
  • Contribute to building a culture that encourages continuous learning, improvement and innovation, and encourages team members to expand their technical skill base.


  • Ph.D. in Molecular Biology, Biochemistry, Cell Biology, Immunology, Biology or equivalent relevant industry experience with a MS or BS degree.


  • A minimum of 5 years of experience in molecular assay development.
  • Technical expertise with qPCR, dPCR, gene expression analysis, gene editing, DNA cloning, gel electrophoresis and other molecular assays.
  • Experience in analytical method development and qualification, and/or implementation of new technologies in a regulated environment (e.g. GxP).
  • Experience with the assessment of new technologies in a fast-paced, learning organization; preferably in a cross-functional setting where impact of new technologies are evaluated across research, development and commercial organizations.
  • Experience in the cell and gene therapy field. 


  • Must have excellent oral and written communication skills.
  • Ability to work independently and collaboratively among cross-functional teams.
  • Ability to work efficiently, prioritize workflow, meet deadlines and balance competing priorities.
  • Excellent analytical skills and scientific/technical expertise.
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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