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03.03.22
South San Francisco, California, United States
Senior Scientist, Translational Pathology Laboratory
Pathology/Nonclinical Development

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers.  We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science.  We are a learning organization, dependent on deep collaborative relationships between our colleagues, partners, and founders.  Our culture is based on Science, Respect, Collaboration and Courage, and it reflects who we are and the environment we are creating.

Position Summary:

We are seeking an experienced and motivated Pathology Scientist to join the Department of Pathology & Nonclinical Development at Lyell, South San Francisco. The ideal candidate will play a pivotal role in designing and conducting high-quality discovery research & translational pathology experiments and analysis to provide key contribution to research and development of Lyell’s next generation reprogrammed T cell therapies for solid tumors.

The successful candidate will collaborate closely with Lyell’s Research groups, including bioinformatics, flow cytometry, in vivo pharmacology, as well as the Clinical Development team, for pivotal pathology assay development and experiments. The ideal candidate will have experience in designing and executing pathology assays for target expression validation and profiling, evaluation of various tumor models as well as clinical biopsy samples for anti-tumor efficacy, mechanism of actions, and/or safety of Lyell’s reprogrammed T cell therapies. 

Essential Functions:

  • In collaboration with Lyell’s research and clinical biomarker teams, design and conduct pathology experiments to understand the expression of Lyell’s novel therapeutic targets, distribution, and phenotypes of reprogrammed therapeutic T cells, as well as investigate tumor infiltrating lymphocytes (TIL) and microenvironment (TME) in solid tumors.
  • Design, develop, and execute tissue -based molecular pathology assays including IHC, ISH, multiplexing (Phenoptics®, CODEX®) using automated platforms and digital image analysis (e.g., HALO®)
  • Analyze, interpret, and present the pathology data in research project team meetings
  • Ensure timely and accurate collection of study data in various database and ELN, and generate high quality pathology study reports for external publications and regulatory filings

Preferred Experience:

  • Deep and up-to-date understanding of immunology, T-cell biology, tumor-infiltrating lymphocytes (TIL), and tumor microenvironment (TME)
  • Relevant and tangible work experience in the oncology therapeutic area, especially in immune-oncology or engineered immune cell-based therapeutics
  • Strong background or ability to learn in the application of statistics and stereology to digital pathology
  • Previous experience in designing, optimizing, executing complex immunofluorescence multiplex tissue-based assays and their application in clinical samples

Preferred Education:

  • M.S. and/or Ph.D. with a minimum of 5 to 8 years of relevant experience (including post-Doc) in Immunology, Oncology, Pathology, or related field

Preferred Additional Skills:

  • Excellent oral and written communication, data organization, and presentation skills
  • Ability to work independently and collaboratively among cross-functional teams
  • Ability to work efficiently, prioritize workflow, meet deadlines, and balance competing priorities
  • Proficiency in the image and statistical data analysis using Prism®, HALO®, InForm®, Phenochart® or equivalents 
  • Previous experience or interest to learn advanced/emerging pathology platforms such as laser microdissection and spatial transcriptomics

At Lyell, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate based on race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status, or any other characteristics protected under applicable federal, state, and local laws.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at careers@lyell.com.

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