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South San Francisco, California, United States
Senior Lab Automation Engineer
Information Sciences

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers.  We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science.  We are a learning organization, dependent on deep collaborative relationships between our colleagues, partners, and founders.  Our culture is based on Science, Respect, Collaboration and Courage, and it reflects who we are and the environment we are creating.


Lyell is looking for an expert Senior Lab Automation Engineer to join the Information Sciences team. Automation Engineers are responsible for helping ensure high quality, reproducible data is generated at Lyell by automating and scaling complex workflows. This will be accomplished by implementing semi/fully automated processes and robotic systems for research and clinical laboratories at multiple sites.


  • Promote culture of automating frequently repeated steps/workflows, driving efficiencies, and ensuring high quality, reproducible data is generated
  • Collaborate with Lyell scientists to understand which steps/workflows in the lab can/should be automated, identify potential automated solutions (including robotics), and clearly propose user-friendly solutions (with short/long term cost benefit analysis)
  • Help create and drive data consistency through lab and data automation
  • Evaluate, select, develop, optimize, test, scale, and productionize new technologies and robotics platforms
  • Identify solutions for automated lab monitoring
  • Collaborate with data/software engineers on the design of software solutions for innovative automated data acquisition and integration, including sample tracking, simplified data entry, and integration of lab data with Lyell’s cloud Data Platform.
  • Collaborate with software engineers and IT to integrate lab instruments with LIMS, ELN, and other laboratory software
  • Continuously find opportunities for efficiency and quality improvement 
  • Ensure that implemented solutions and processes are in compliance with established quality, compliance, and regulatory processes
  • Work collaboratively in multi-functional groups, such as software engineering, biological sciences, data sciences, regulatory, and manufacturing
  • Document processes, including automated workflows 


  • Production experience (+3 years) with Hamilton VENUS control software.
  • Experience with NGS, flow cytometry, and imaging instruments and data
  • Exposure to Python, Java, or other object oriented programming languages
  • A background in molecular biology or biochemistry is desired, but not required


  • Experience working with and building relationships with external lab instrument/robotics/software vendors
  • Production experience with high-throughput laboratory instrumentation, automation scheduling software (Green Button Go, Cellario, Genera, Momentum), and other robotic liquid handling systems (Agilent, Tecan, Biomek, Echo, etc.)
  • Experience working in a regulated environment 
  • Experience with software development standard methodologies such as issue tracking and source control
  • Exposure to rest or soap apis
  • Excellent oral and written communication skills
  • Ability to work independently and collaboratively among multi-functional teams, with a particular understanding for and drive to solve data issues faced by research and clinical scientists.
  • Ability to work efficiently, prioritize workflow, meet deadlines and balance competing priorities.
  • Excellent analytical skills and scientific/technical expertise

At Lyell, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate based on race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status, or any other characteristics protected under applicable federal, state, and local laws.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at

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