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South San Francisco, California, United States
Manager, IT Change Management
Business Support
At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.


The individual in this role will be responsible for managing the lifecycle for all technology change activities from request submission, scheduling, implementation, to documented records/reports ensuring that the company complies with SOX and IT Governance, Risk and Compliance (GRC) controls This role will manage the request queue to develop an efficient change schedule and communication plan, with minimum risk to Lyell, and will work directly with all stakeholders.


  • Review and record Requests For Change (RFC’s)
  • Categorize and prioritize change requests according to business objectives
  • Manage the transition of changes from the development team to operations
  • Accept or reject RFC’s
  • Develop a strategy for CAB approvals in a dynamic environment
  • Coordinate the review of documentation related to changes (implementation and rollback plans, testing and validation plans)
  • Mediate conflicts related to the change schedule where necessary
  • Create and circulate the change schedule
  • Conduct Post Implementation Reviews (PIR’s) after the implementation of changes
  • Maintain all change documentation (policies, procedures, templates, etc.)
  • Produce management reports
  • Maintain the IT Change Calendar and schedule all changes
  • Manage, coordinate, monitor, and report on change activities
  • Audit and manage the Change and Release Management process improvement cycle and ensure compliance with Sarbanes-Oxley (SOX) IT general computer control requirements
  • Play a key role in collaborating with other IT teams in ensuring the highest level of operational service delivery
  • Act as a focal point for all escalation and communication activities related to users and IT teams to ensure effective and efficient execution of change activities. Highlight and escalate risk & issues to management 


  • BA/BSc in Information Technology or a related field with a minimum of 10 years’ experience; or
  • MBA or MSc in Information Technology or a related field with a minimum of 7 years’ experience
  • Minimum 5 years’ experience in an IT change management role
  • Demonstrated experience in IT Service Management (ITSM) with proven track record in establishing, managing IT change release processes and activities within a global/regional organization
  • Proven experience in reviewing and collaborating on necessary changes to organizational processes, policies, and skills to support sustainable change


  • Skilled in creating custom change management solutions to lead change in complex transformation efforts
  • Excellent communication and training skills
  • Strong analytical skills, with application to change management measures and metrics
  • Ability to understand context, evaluate risk, and understand the impact of change with the ability to challenge appropriately
  • Strong working knowledge of Okta Lifecycle Management 
  • Proficiency with both Google g-Suite and Microsoft Office Suite 
  • Strong understanding of the biotechnology/pharmaceutical industry 
  • Skilled decision-maker with the ability to clearly articulate decisions in a team environment
  • Demonstrated ability to execute projects and process improvement activities
  • Results oriented team player
  • Self-starter with ability to manage rapidly changing priorities and opportunities
  • Ability to analyze data trends and report/communicate appropriately
  • Strong organizational skills, ability to establish priorities, multi-task, handle competing priorities and follow through on all open items/tasks
  • Working knowledge and understanding in the full technology stack such as IT Infrastructure, Security, App/Dev, Cloud Models, and Technological Change
At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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