iPSC Research
South San Francisco, California, United States

Scientist I, Metabolism

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.

Lyell Immunopharma is seeking a qualified candidate to join our newly established R&D center in South San Francisco and Seattle as an experienced Scientist II in the T cell rejuvenation team. The ideal candidate will play a principal role in developing culture conditions for our rejuvenated T cells.

Essential Functions:  

In this role you will be responsible for:

  • The design and development of new protocols to test hypotheses
  • Think creatively to solve problems and develop new technology in a collaborative, team environment
  • Analyze/interpret results and effectively communicate them to other scientists on the team
  • Responsible for the completion of research, experiments, and assignments that have an impact on functional/technical goals
  • Participate and thrive in an interactive, team-oriented culture
  • Responsible for mentoring and possibly managing associates
  • Involvement in steering the scientific direction of external collaborations

Preferred Experience:

  • Expansive experience with stem cell biology and/or metabolism
  • Consistent record of innovative contributions to stem cell biology and/or energy metabolism, as evidenced by first / senior-authored publications in top-tier journals and patent inventorship.
  • Strong cell/molecular biology knowledge and experience.
  • Strong experience with pluripotent or somatic stem cell culture work (culture, expansion, media formulations, passaging, preservation) will be considered as a plus.

Preferred Education:

  • Degree in energy metabolism, metabolism of stem cells (or cancer cells), stem cell biology, or related field. MS will be considered for the position accordingly with their professional experience.
  • Deep knowledge in several biologic fields: energy metabolism, stem cell metabolism, stem cell biology, and cellular reprogramming.

Preferred Additional Skills: 

  • Strong experience with general cell culture work (culture, expansion, media formulations, passaging, preservation).
  • Extensive experience in flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus
  • Proven hands-on experience with cellular metabolism using a variety of readout technologies (i.e. quantifying OCR, mitochondrial respiration, glycolytic activity, substrate oxidation, and metabolic switching)

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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