Vector Biology & Manufacturing
Seattle, Washington, United States

Scientist II, Vector Sciences

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.

This role resides in the Vector Sciences group with the Technical Operations function at Lyell. You will work collaboratively within the Vector Sciences project team and supports technological transfers to the LyFE manufacturing facility in Bothell in collaboration with Lyell’s MSAT team to support the production pipeline.  In this role you will provide technical leadership for viral vector downstream process development and characterization to support clinical and commercial manufacturing. The responsibilities also include authoring technical reports, process transfer documents, process control strategy and process related documents.

The scientist is responsible for keeping abreast of current publications in their field and can independently integrate ideas from these publications into current projects. Networks with colleagues outside their own area of expertise.


  • Optimize downstream processes for lentiviral manufacturing using liquid chromatography unit as well as filtration operations
  • Design and execute downstream process development studies to support viral vector clinical manufacturing process
  • Data analysis related to downstream processes and assays and experimental outcomes
  • Development of novel downstream processes for viral products
  • Perform normal flow and tangential flow filtration operations, chromatographic separations, in-process analytical testing as required
  • Developing GMP downstream processes and assay development and performance regarding downstream development
  • Leading and assisting in research, product and process development for current and novel work which includes hands-on work
  • Writes, reviews, and approves R&D protocols, batch records, and reports in support of RD, process development.
  • Write SOPs, work instructions, test methods, and other product development and R&D documents
  • Author and review technical reports, process descriptions, process control strategy and process related documents
  • Support technology transfer of clinical and/or commercial process
  • Collaborate with Upstream, Analytical, Formulation, Drug Product and MSAT team to support ongoing pipeline products
  • Participate and influence the cross functional team to advance CMC activities
  • Coordinates lab work with members of the vector development team
  • Ability to work independently with minimal or no supervision
  • Communicate and discuss results with other scientists
  • Delivers presentations and contributes to abstracts, posters or publications, both internally and externally
  • Responsible for mentoring and possibly managing junior associates
  • Can be involved in steering the scientific direction of external collaborations


  • MSc in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline with a minimum of 9 years’ experience within the area of focus; or
  • PhD in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline of 4 years’ experience within the area of focus.


  • As a Scientist II the scientist must be skilled and accomplished in downstream viral vector processes 
  • Field and execute all scientific research and development strategies independently while collaborating with Upstream and PD/MSAT teams. The candidate needs ample experience in downstream unit operations such as vector harvest, liquid chromatography, and TFF.
  • Extensive knowledge and experience in the field of software used in chromatography and filtration steps. The candidate needs to have demonstrated knowledge of process design, optimization, and characterization for early to late-stage programs.


  • Skilled and accomplished in the field of downstream vector molecule processing, preferably of lentiviral vectors
  • Experience in developing downstream processes for GMP manufacturing and/or working experience in GMP facilities performing downstream operations  
  • In-depth knowledge of software used in planning and controlling instruments used for liquid chromatography and tangential flow filtration (i.e. Unicorn, KF Komm)
  • Experience with electronic lab notebooks
  • Able to design complex experiments with scientific rationale
  • Understands the theoretical basis and experimental objectives and how they fit into the overall project goals; uses broad knowledge of current literature to drive the direction of the project
  • Able to critically analyze and interpret data
  • Developing skills in critical interpretation of scientific data and problem solving and reporting of scientific data
  • Knowledgeable and deeply proficient in a range of technical skills and the ability to teach junior colleagues
  • Highly proficient in using Microsoft Office (Word, Excel, PowerPoint)
  • Effectively communicate and discuss results with other scientists on the team; general comfort with presenting data across the company and externally
  • Strong ability to work in a matrixed environment


  • Prolonged periods sitting of at a desk and working on a computer and standing, reaching and bending

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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