Pathology/Nonclinical Development
South San Francisco, California, United States

Senior Research Associate, InVivo Pharmacology

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Respect, Science, Courage and Collaboration and it reflects who we are and the environment we are creating.


We are seeking an experienced Senior Research Associate to join our In Vivo Pharmacology group in the Department of Pathology & Nonclinical Development. The group’s mission is to evaluate the efficacy, mechanism, and safety of our novel T-cell therapy candidates in vivo pharmacology studies using various mouse models, providing excellence and support to the Lyell Research groups and to our development pipeline projects. This position will play a key role in setting up, executing, and reporting our in vivo pharmacology studies, and collaborating with scientists across Lyell.


  • Maintenance of a highly functioning in vivo and ex vivo labs, working with the other members of the In Vivo Pharmacology group and other cross-functional scientists.
  • Proficient in basic animal handling, including blood sample collection and necropsy with organ/tumor sample collection.
  • Setup and execution of in vivo studies using xenograft and syngeneic mouse models of solid tumors including animal preparation/surgery, tumor implantation (s.c., i.p., i.v., or orthotopic), preparation and dosing of therapeutic T cells and other agents via various routes of administration, tracking of tumor growth (eg., bioluminescence/fluorescence, micro-CT, and caliper measurements), collection of blood, tissue, tumor samples, and monitoring of animal health.
  • Ex vivo study responsibilities include cell culture, collection and processing of organs and tumor samples for immunological and pathological analysis
  • Collection, entry, analysis, and presentation of study data to project teams
  • Generation and maintenance of electronic lab notebook (ELN) reports, including basic statistical data analysis.


  • B.Sc. in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 7 years’ experience within the area of focus; or
  • M.Sc. in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 5 years’ experience within the area of focus;


  • Proficient in executing various xenograft and syngeneic tumor models using immunocompromised and immune-competent mice with adoptive T cell transfer
  • Proficient with mammalian cell culture techniques such as cell line passaging, cryopreservation and cell thawing, and cell counting.
  • Proficient using and analyzing high-parameter flow cytometry


  • Data analysis using software packages (FlowJo, FCS Express, Prism)
  • Experience using and analyzing common immunology and oncology related to the specific project; cell therapy experience is ideal, more complex experience a plus
  • Proficient in sterile tissue culture technique and experience working with human cells
  • Experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus
  • Experience in data production and reporting for IND-enabling studies
  • Additional specific experience related to the area of focus may be required

Lyell offers its employees a range of compensation and benefits. To assist you with your
decision to apply for this role, the following information and links to our site highlight our
competitive market position and support to our employees and their dependents.

The salary range for this position is $110,000 to $125,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found here.

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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