Bothell, Washington, United States

Senior Associate, Manufacturing

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Respect, Science, Courage and Collaboration and it reflects who we are and the environment we are creating.


The incumbent is responsible for supporting the operations in our cGMP clinical manufacturing site producing plasmids, viral vectors, and autologous cell therapies.  This role is primarily responsible for performing daily manufacturing operations.  The role will also be responsible for supporting additional manufacturing responsibilities.


Execute the Day-to-Day Manufacturing Processing

  • Assist in development and implementation of GMP SOPs related to Manufacturing Operations.
  • Execute manufacturing operations safely, as scheduled, and right the first time for delivery of treatment to patients.
  • Maintain production facilities at a high standard of cleanliness and organization.
  • Perform equipment maintenance and calibrations as required.
  • Maintain appropriate level of training for assigned responsibilities.
  • Identify and report risks in the manufacturing areas that could negatively impact the quality of patient therapies.
  • Ensure timely review and closure of electronic batch records, exceptions, deviations.
  • Assist with CAPA and change controls as needed.

Collaborate Effectively

  • Be a team player, offer assistance, and respond well to requests for help from team members.
  • Use strong communication and build relationships.
  • Demonstrate technical acumen, operational understanding, and GMP compliance.
  • Support operational excellence initiatives.
  • Support a culture of safety and GMP compliance.
  • Identify opportunities for continuous improvement.


  • BSc degree in a relevant field (eg biochemistry, chemical engineering, bioengineering, or related scientific field)


  • Minimum of 6 years’ experience in GMP biopharmaceutical operations preferably with experience in cell therapy, mammalian cell culture, and/or microbial fermentation.
  • Experience with quality management systems (e.g. Deviations, CAPAs, Change Management).
  • Experience with electronic systems such as MES and ERP.


  • Familiar with regulations for GMP manufacturing of drug substance, drug products, cellular and gene therapies, and viral vectors for clinical phase therapies.
  • Proven track record in cGMP manufacturing operations, including producing therapies safely and right the first time.
  • Fast learner, adaptable, and excellent cross-collaboration and inter-personal skills.
  • The desire and ability to work in a fast-paced, start-up environment.


The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of the job. While performing their duties, the employee must be able to do the following:

  • Confirm visual information in the environment such as batch record and SOP steps were completed properly, parameters on equipment and computer screens, status of materials and equipment, and perform visual inspection of materials and product.  A vision test may be required.  Use of corrective lenses is acceptable.
  • Stand and step over a gowning bench (12-24”) and aseptically don head-to-toe non-sterile and sterile gowns.


Due to the nature of our autologous cell therapies and the need to deliver life-saving treatments to our patients as timely as possible, shift work, weekend work, and holiday work will be required. We are looking for passionate team members to join our team that are willing to learn, grow, and evolve with us.  Part of this evolution will be to work together to continually assess and modify our shift structure to best support delivering these critical products to our patients.

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.
Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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