Translational Science
South San Francisco, California, United States

Senior Scientist, Clinical Biomarkers

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.


The incumbent designs, develops and supports the implementation of clinical biomarker assays to interrogate the pharmacokinetics (PK), pharmacodynamics (PD) and mechanism of action (MOA) of cellular therapies.


  • Independently design, validate and support implementation of clinical flow cytometry, single cell RNA sequencing (scRNAseq) and ex vivo cell-based assays for use in evaluating clinical biomarker samples
  • Critically analyze experimental results and interpret complex datasets that inform the testing of clinical research hypothesis
  • Develop, trouble-shoot and optimize biomarker sample collection, processing and analysis solutions for interrogating PK, PD and MOA by flow cytometry, scRNAseq and cell-based assays in the clinical trial setting
  • Collaborate with expert internal and CRO-based colleagues to support the implementation of next-generation sequencing (NGS), epigenetic (ATACseq) and tissue-based (IHC, ISH) biomarker analysis platforms
  • Serve as subject matter expert and present assay development, clinical biomarker data and interpretations to project teams, other functional groups (e.g., non-clinical research, process development) and/or to external stakeholders.
  • Author assay protocols, SOPs, clinical lab manual sections and related materials for documentation, implementation and communication of clinical biomarker-related results and protocols
  • Evaluate new technologies, methods and platforms to enhance the quantity, quality and impact of clinical biomarker data
  • Maintain high level of technical and scientific expertise leveraging scientific literature, conferences, internal meetings and training opportunities


  • BSc in immunology, oncology or related field with a minimum of 13 years’ experience within the area of focus; or
  • MSc in immunology, oncology or related field with a minimum of 11 years’ experience within the area of focus; or
  • PhD in immunology, oncology or related field with a minimum of 6 years’ experience within the area of focus


  • Breadth and depth of experience in studying immune cell biology using in vitro and ex vivo research technologies with an emphasis on high dimensional flow cytometry and scRNAseq
  • Strong expertise in techniques, such as primary cell tissue culture, to interrogate immune cell activity in physiologically relevant in vitro / ex vivo model systems
  • Experience either directly validating or working closely with a CRO to validate flow cytometry assays at the GCLP and/or CAP/CLIA level
  • Application of GLP/GCLP regulatory guidance and industry white papers relevant to clinical biomarker assay validation and implementation
  • Expertise in the use of relevant data analysis software (FloJo, CellEngine, Prism, Excel, Spotfire etc.)
  • Experience in the development of clinical immunogenicity assays


  • Demonstrated ability to build, lead and motivate teams across multiple functions
  • Collaborative leadership style
  • Proven expertise in experimental design and application of flow cytometry and immune cell-based assay platforms to test hypotheses in the areas of immune-oncology and/or T cell biology.
  • Direct experience adapting discovery stage assays used in non-clinical biomarker discovery for use in samples from early-stage clinical trials.
  • Expertise in developing and implementing robust, validated clinical flow cytometry and cell-based assays in the biotherapeutic and/or cell therapy development space.
  • Experience working with bioinformatics colleagues to analyze and interpret NGS data
  • Ability to work independently as well as on interdisciplinary teams to achieve organizational objectives
  • Written and oral communications skills to function efficiently and effectively in a highly collaborative environment with both internal and external stakeholders
  • Ability to take initiative, leverage multiple sources of knowledge and expertise to make decisions and meet complex scientific and operational challenges
  • Ability to work efficiently, prioritize workflow, meet deadlines, balance competing priorities and adapt to change


Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.

The salary range for this position is $160,000 to $175,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found on our company website,

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”

We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.

Apply Now