Research
Seattle, Washington, United States
12/19/22

Scientist I, T cell Discovery

At Lyell, our vision is to develop curative cell-based immunotherapies for solid tumor cancers. We have innovative science originating from our founder’s world class labs and a unique and disruptive approach to research and development. Our company is first and foremost focused on understanding the science. We are a learning organization, dependent on deep collaborative relationships between all of our colleagues, partners and founders. Our culture is based on Science, Respect, Collaboration and Courage and it reflects who we are and the environment we are creating.
 
We are seeking a T cell Scientist to join our discovery and development team in Seattle, Washington. You will participate in exploratory and new pipeline development, explore and apply innovative research biology approaches to develop next-generation T cell therapies.

KEY ROLE AND RESPONSIBILITIES:

  • Design, execute and critically analyze in vitro experiments to support research and development of T cell therapies with scientific rationale
  • Able to manage their workload, design and perform bench activities independently or with minimal supervision 
  • Critically analyze experiments, interpret complex data, and draw appropriate conclusions with scientific rigor 
  • Able to troubleshoot critical issues or problems, and determine causes and possible solutions 
  • Able to manage project timelines and perform time sensitive experiments to drive discovery programs accordingly with departmental, functional and external stakeholders 
  • Contribute significantly and independently to multiple projects and execute in parallel 
  • Maintain complete laboratory records and prepare technical data reports and presentations. Experience in electronic lab notebook is a plus.
  • Participate and thrive in an interactive, team-oriented culture and be able to work well in a highly cross-functional team environment
  • Comfortably working with his/her team members in the laboratory

PREFERRED EDUCATION:

  • BSc in immunology, oncology or related field with a minimum of 9 years’ experience within the area of focus; or
  • MSc in immunology, oncology or related field with a minimum of 7 years’ experience within the area of focus; or
  • PhD in immunology, oncology or related field with a minimum of 0-2 years’ experience within the area of focus

 PREFERRED EXPERIENCE:

  • The ideal candidate will have direct hands-on experience in establishing in vitro assays for adoptive T cell therapies.
  • Expertise in human T cell isolation, culture, engineering and complex cell-based assays for functional characterization (such as cytotoxicity assays, cytokine detections and T cell phenotypes by flow cytometry) and phenotypic analysis of human T cells.
  • Consistent record of innovative contributions to study of T cell functions (Publications in top-tier journals and/or patent inventorship)
  • Strong experience with general cell culture work (culture, expansion, media formulations, passaging, preservation, co-culture systems).
  • Extensive experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus
  • Strong molecular biology knowledge and experience (i.e. PCR, Western blots, RT-PCR, qPCR, designing constructs); more complex experience and design is a plus
  • Tasked with leading projects (either technical or scientific project specific) under guidance, designing the timelines and experiments, with opportunities to present data to leadership is applicable to the role.
  • You will be responsible for designing and executing experiments for the scientific research and development strategies with the input of the supervisor. Works independently with their team on a variety of complex assays and projects. Comfortable with analysis of situations or data that require an in-depth evaluation of variable factors. Exercise independent judgment in selecting methods, techniques and evaluation criteria for obtaining results.

KNOWLEDGE, SKILLS AND ABILITIES:

  • Scientific background in immuno-oncology and adoptive cell therapy.
  • Design, execution, analysis and documentation of experiments supporting research and development of T cell therapies
  • Tissue culture and manipulation of both mammalian cell lines and primary human lymphocyte (PBMC, T cells)
  • Lentivirus vector transduction and production
  • Apply up-to-date developments in cell therapy-related technologies to design and create the next generation cell therapy platforms
  • Extensive experience using and analyzing broad range of immunology and oncology assays; cell therapy experience ideal, more complex experience a plus
  • Extensive experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus
  • Extensive experience in sterile tissue culture technique and working with human cells
  • Experience in data production and reporting for IND-enabling studies

Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.

The salary range for this position is $120,000 to $135,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.

Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found on our website. 

At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees.

Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
 
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine.  The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.”
 
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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