1. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells

    Cancer Immunology Research, June 1, 2016

    DOI: 10.1158/2326-6066.CIR-15-0231

    Eugenia Zah; Meng-Yin Lin; Anne Silva-Benedict; Michael C. Jensen; Yvonne Y. Chen

  2. CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

    Cancer Discovery, March 1, 2023

    DOI: 10.1158/2159-8290.CD-22-0964

    Sarah M. Larson, Christopher M. Walthers, Brenda Ji, Sanaz N. Ghafouri, Jacob Naparstek, Jacqueline Trent, Jia Ming Chen, Mobina Roshandell, Caitlin Harris, Mobina Khericha, Thomas Schweppe, Beata Berent-Maoz, Stanley B. Gosliner, Amr Almaktari, Melanie Ayala Ceja, Martin S. Allen-Auerbach, Jonathan Said, Karla Nawaly, Monica Mead, Sven de Vos, Patrick A. Young, Caspian Oliai, Gary J. Schiller, John M. Timmerman, Antoni Ribas, and Yvonne Y. Chen

  3. CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

    The Journal of Clinical Investigation, May 3, 2022

    DOI: 10.1172/JCI150807

    Silvia Arcangeli, Camilla Bove,Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, and Monica Casucci

  4. Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

    Leukemia, May 2016

    DOI: 10.1038/leu.2015.247

    D Sommermeyer, M Hudecek, P L Kosasih, T Gogishvili, D G Maloney, C J Turtle, S R Riddell

  5. Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy

    Cancer Discovery, September 2021

    DOI: 10.1158/2159-8290.CD-20-1677

    Gregory M Chen, Changya Chen, Rajat K Das, Peng Gao, Chia-Hui Chen, Shovik Bandyopadhyay, Yang-Yang Ding, Yasin Uzun, Wenbao Yu, Qin Zhu, Regina M Myers, Stephan A Grupp, David M Barrett, Kai Tan

  6. Favorable Activity and Safety Profile of Memory-Enriched CD19-Targeted Chimeric Antigen Receptor T-Cell Therapy in Adults with High-Risk Relapsed/Refractory ALL

    Clin. Cancer Research, February 2023

    DOI: 10.1158/1078-0432.CCR-22-2038

    Ibrahim Aldoss, Samer K Khaled, Xiuli Wang, Joycelynne Palmer, Yan Wang, Jamie R Wagner, Mary C Clark, Jennifer Simpson, Jinny Paul, Vibhuti Vyas, Sheng-Hsuan Chien, Anthony Stein, Vinod Pullarkat, Amandeep Salhotra, Monzr M Al Malki, Ahmed Aribi, Karamjeet Sandhu, Sandra H Thomas, Lihua E Budde, Guido Marcucci, Christine E Brown, Stephen J Forman

  7. Engineering potent chimeric antigen receptor T cells by programming signaling during T-cell activation

    Scientific Reports, September 12, 2024

    DOI: 10.1038/s41598-024-72392-1

    Aileen W. Li, Jessica D. Briones, Jia Lu, Quinn Walker, Rowena Martinez, Hajime Hiraragi, Bijan A. Boldajipour, Purnima Sundar, Shobha Potluri, Gary Lee, Omar A. Ali & Alexander S. Cheung

  8. Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

    Nature Biotechnology, January 15, 2018

    DOI: 10.1038/nbt.4047

    Alexander S Cheung, David K Y Zhang, Sandeep T Koshy and David J Mooney

  9. Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

    Science, December 11, 2020

    DOI: 10.1126/science.abb9847

    Sri Krishna, Frank J. Lowery1, R. Copeland, Bahadiroglu, Ratnadeep Mukherjee, Li Jia, James T. Anibal, Abraham Sachs, Serifat O. Adebola, Devikala Gurusamy, Zhiya Yu, Victoria Hill, View Jared J. Gartner, Yong F. Li, Maria Parkhurst, Biman Paria, Pia Kvistborg, Michael C. Kelly, Stephanie L. Goff, Grégoire Altan-Bonnet, F. Robbins, Steven A. Rosenberg

  10. T cell stemness and dysfunction in tumors are triggered by a common mechanism

    Science, March 29, 2019

    DOI: 10.1126/science.aau0135

    Suman Kumar Vodnala, Robert Eil, Rigel J. Kishton, Madhusudhanan Sukumar, Tori N. Yamamoto, Ngoc-Han Ha, Ping-Hsien Lee, MinHwa Shin, Shashank J. Patel, Zhiya Yu, Douglas C. Palmer, Michael J. Kruhlak, Xiaojing Liu, Jason W. Locasale, Jing Huang, Rahul Roychoudhuri, Toren Finkel, Christopher A. Klebanoff, Nicholas P. Restifo

  11. c-Jun overexpression in CAR T cells induces exhaustion resistance

    Nature, December 4, 2019

    DOI: 10.1038/s41586-019-1805-z

    Rachel C. Lynn, Evan W. Weber, Elena Sotillo, David Gennert, Peng Xu, Zinaida Good, Hima Anbunathan, John Lattin, Robert Jones, Victor Tieu, Surya Nagaraja, Jeffrey Granja, Charles F. A. de Bourcy, Robbie Majzner, Ansuman T. Satpathy, Stephen R. Quake, Michelle Monje, Howard Y. Chang & Crystal L. Mackall

  12. Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response

    Current Opinion in Immunology, March 4, 2013

    DOI: 10.1016/j.coi.2013.02.005

    Michel DuPage and Tyler Jacks

  13. Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues

    Clinical Cancer Research, November 16, 2016

    DOI: 10.1158/1078-0432.CCR-16-2083

    Ashwini Balakrishnan, Tracy Goodpaster, Julie Randolph-Habecker, Benjamin G. Hoffstrom, Florencia G. Jalikis, Lisa K. Koch, Carolina Berger, Paula L. Kosasih, Anusha Rajan, Daniel Sommermeyer, Peggy L. Porter, and Stanley R. Riddell

  14. Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells

    Cancer Immunology Research, October 29, 2014

    DOI: 10.1158/2326-6066.CIR-14-0163

    Carolina Berger, Daniel Sommermeyer, Michael Hudecek, Michael Berger, Ashwini Balakrishnan, Paulina J. Paszkiewicz, Paula L. Kosasih, Christoph Rader and Stanley R. Riddell

  15. Developmental Relationships of Four Exhausted CD8(+) T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

    Immunity, May 19, 2020

    DOI: 10.1016/j.immuni.2020.04.014

    Jean-Christophe Beltra, Sasikanth Manne, Mohamed S. Abdel-Hakeem, Makoto Kurachi, Josephine R. Giles, Zeyu Chen, Valentina Casella, Shin Foong Ngiow, Omar Khan, Yinghui Jane Huang, Patrick Yan, Kito Nzingha, Wei Xu, Ravi K. Amaravadi, Xiaowei Xu, Giorgos C. Karakousis, Tara C. Mitchell, Lynn M. Schuchter, Alexander C. Huang, E. John Wherry

  16. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

    Annual Review of Immunology, January 24, 2019

    DOI: 10.1146/annurev-immunol-041015-055318

    Laura M. McLane, Mohamed S. Abdel-Hakeem, and E. John Wherry

  17. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion

    National Academy of Sciences, June 18, 2019

    DOI: 10.1073/pnas.1905675116

    Hyungseok Seo, Joyce Chen, Edahí González-Avalos, Daniela Samaniego-Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. López-Moyado, Romain O. Georges, Wade Zhang, Atsushi Onodera, Cheng-Jang Wu, Li-Fan Lu, Patrick G. Hogan, Avinash Bhandoola, and Anjana Rao

  18. NR4A transcription factors limit CAR T cell function in solid tumours

    Nature, February 27, 2019

    DOI: 10.1038/s41586-019-0985-x

    Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, Chan-Wang J. Lio, Laura J. Hempleman, Takashi Sekiya, Akihiko Yoshimura, James P. Scott-Browne & Anjana Rao

  19. Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

    Cancer Cell, February 28, 2021

    DOI: 10.1016/j.ccell.2020.11.005

    Shivani Srivastava 1, Scott N Furlan 2, Carla A Jaeger-Ruckstuhl 3, Megha Sarvothama 3, Carolina Berger 3, Kimberly S Smythe 3, Sarah M Garrison 3, Jennifer M Specht 4, Sylvia M Lee 4, Robert A Amezquita 5, Valentin Voillet 5, Vishaka Muhunthan 3, Sushma Yechan-Gunja 3, Smitha P S Pillai , Christoph Rader, A McGarry Houghton, Robert H Pierce 3, Raphael Gottardo 5, David G Maloney, Stanley R Riddell

  20. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

    Nature Biotechnology, April 2014

    DOI: 10.1038/nbt.2859

    Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby, Prapti Pokhare, Shuqiang Li, Michael Morse, Niall J Lennon, Kenneth J Livak, Tarjei S Mikkelsen, John L Rinn