South San Francisco, California, United States

Scientist I, T Cell Rejuvenation

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. At Lyell, our goal is to change that. We are a clinical-stage T-cell reprogramming company advancing a diverse pipeline of cell therapies for solid tumors based on our innovative technologies. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to defeat solid tumors, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.
The ideal candidate for Scientist I on the T Cell Rejuvenation team will play a pivotal role in spearheading the development of the next generation of T cell immunotherapies. This individual will contribute to new hypotheses, execute research plans, and collaborate with team members to advance this disruptive technology.


  • Design and implement complex experiments independently with scientific rationale
  • Conduct thorough analyses, draw critical conclusions, and articulate findings effectively to both internal teams and the external scientific community and
  • partners
  • Create and maintain electronic lab notebooks, generate comprehensive reports, contribute to publications, and deliver presentations.
  • Think creatively to solve problems and develop new technology
  • Demonstrate strong interpersonal and collaboration skills, coupled with self-motivation, meticulous attention to detail, independent thinking, and seamless integration into a high-achieving, team-oriented environment


  • Ph.D. in cancer biology, immunology, cell biology, molecular biology, or a related field
  • M.S. with extensive professional experience will be considered
  • Strong experience with cell culture (expansion, media formulations, passaging, cryopreservation)
  • Relevant experience with primary cell culture, tumor tissue dissociation, TIL, stem cells, reprogramming, organoid, metabolism, and aging is preferred.
  • Extensive experience with flow cytometry assays and analysis
  • In-depth knowledge and experience in cell/molecular biology
  • Preferential expertise in tumor biology and immunology
  • Familiar with molecular biology assays
  • A proven track record of high productivity and scientific publications in peer-reviewed journals and patent inventorship


  • Comprehensive understanding of the theoretical basis and experimental objectives, aligning them with the overall project and broader company goals;
  • Ability to provide input based on knowledge of literature to guide project direction.
  • Proficient and knowledgeable in various technical skills, including cell culture and flow cytometry assays, with the ability to mentor junior colleagues.
  • Highly skilled in using data analysis software packages (Prism, Flow Jo, etc.).
  • Effective communication, collaboration, and results discussion with other scientists on the team. Strong ability to work efficiently in a matrixed environment.
Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.
The salary range for this position is $120,000 to $135,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental, and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits include 18 days’ vacation, 9 days’ sick leave, eight observed holidays, and a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found here.
At Lyell, we believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate based on race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.
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