Corporate IT
California, United States

Principal Systems Administrator

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. At Lyell, our goal is to change that. We are a clinical-stage T-cell reprogramming company advancing a diverse pipeline of cell therapies for solid tumors based on our innovative technologies. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to defeat solid tumors, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency.  This hybrid role can be based out of California or Washington.  

The individual in this role supports the organization's system infrastructure needs on-premises and in the cloud. This role will support network security, infrastructure maintenance and design, office build-outs, remote connectivity, virtualization, on-premise, and close migrations, working with the team to anticipate and respond to the needs of our internal systems.


  • Day-to-day operations and maintenance of data center and network systems, including but not limited to VMware vSphere cluster w/ iSCSI storage, RDP, and a Cisco Meraki,
    and Palo Alto Networks
  • Monitoring and responding to events related to systems performance and outages (tools include Veeam ONE, and Meraki dashboard, among others)
  • Monitor backup status and health and troubleshoot any exceptions to daily backups.
  • Mobile Device Management – including policy maintenance and automated imaging and patching of Windows and IOS devices.
  • Configuring on-site servers and services and SaaS applications and services. This would include things like the current major release of Windows Server (and associated
    roles/features), Google GSuite, various Office 365 components, and Okta SSO, among others.
  • Providing guidance and administrative support to support staff focused on end-user computing systems, as well as handling escalations when required
  • Maintaining up-to-date documentation on project status and systems configuration
  • Provide Level 3 support for ServiceDesk
  • Support lab infrastructure, including software and attached equipment.


  • BA/BSc in an information technology field with a minimum of 13 years experience; or MBA or MSc in an information technology field with a minimum of 10 years experience
  • Minimum of 7 years of IT System Administration experience with a wide range of systems across MacOS, Windows, and Linux, in addition to management of on-prem and SaaS applications such as GSuite, O365, OKTA, Jira, Slack, etc
  • Extensive demonstrated experience with Windows Servers, VMware vSphere, Horizon View, Mobile Device Management (MDM), Active directory
  • Proven experience in network administration and a strong understanding of fundamentals (routing and switching, firewall rules, etc.)
  • Experience managing and monitoring system backups
  • Experience with one or more programming languages (Python, Ruby, PowerShell, etc..) relevant to scripting and automation
  • Experience in managing VPN, telecommunication, and video conferencing solutions
  • Ability to manage large projects along with excellent oral and written communication skills
  • Ability to work independently and collaboratively among cross-functional teams
  • Strong collaboration, communication, and time management skills
  • Ability to work efficiently, prioritize workflow, meet deadlines, and balance competing priorities.
  • Excellent analytical skills and scientific/technical expertise
Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents.
The salary range for this position is $200,000 and $220,000 annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan.
Our Employee Benefits program is extensive and includes subsidized medical, dental, and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include 18 days’ vacation, 9 day’s sick leave, 8 observed holidays as well as a floating holiday. We also have a summer and a winter office shutdown. More information on our extensive benefits offering can be found here.
At Lyell, we believe that the highest-performing teams include people from various backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate based on race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.
We’ve learned from experience that some of the best people don’t always match our requirements perfectly. If you’re interested and think you could fit, please don’t hesitate to apply.
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